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A new generation of information and communication infrastructures, including advanced Internet computing and Grid technologies, promises to enable more direct and shared access to more widely distributed computing resources than was previously possible. Scientific and technological collaboration, consequently, is more and more coming to be seen as critically dependent upon effective access to, and sharing of digital research data, and of the information tools that facilitate data being structured for efficient storage, search, retrieval, display and higher level analysis. The February 2003 report of the Atkins Committee to the U.S. NSF Directorate of Computer and Information System Engineering urged that funding be provided for a major enhancement of computer and network technologies, thereby creating a cyberinfrastructure whose facilities would support and transform the conduct of scientific and engineering research. The articulation of this programmatic vision reflects a widely shared expectation that solving the technical engineering problems associated with the advanced hardware and software systems of the cyberinfrastructure will yield revolutionary payoffs by empowering individual researchers and increasing the scale, scope and flexibility of collective research enterprises. Animated by much the same vision, the UK e-Science Core Programme has been engaged in developing an array of open standards middleware platforms, intended to support Grid enabled science and engineering research.   This paper, however, argues that engineering breakthroughs alone will not be enough to achieve the outcomes envisaged for these undertakings. Success in realizing the potential of e-Science – and other global collaborative activities supported by the "cyberinfrastructure," if it is to be achieved, more likely will be the resultant of a nexus of interrelated social, legal and technical transformations.